Regenerating islet-derived protein 3-alpha

Definition:

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.

References:

[1]. Heather L Cash, et al. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science. 2006 Aug 25;313(5790):1126-30. [Content Brief]

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