Ribonuclease SLFN12
Definition:
References:
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[1]. Colin W Garvie, et al. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun. 2021 Jul 16;12(1):4375. [Content Brief]
[2]. Dianrong Li, et al. Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol Cell. 2019 Sep 19;75(6):1103-1116.e9. [Content Brief]
[3]. Jie Chen, et al. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat Commun. 2021 Oct 27;12(1):6204. [Content Brief]
[4]. Marc D Basson, et al. Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Cell Physiol Biochem. 2018;48(3):1274-1290. [Content Brief]
[5]. Bo Yan, et al. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. Cell Chem Biol. 2022 Jun 16;29(6):958-969.e5. [Content Brief]
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