RNA-binding region-containing protein 3

Definition:

Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

References:

[1]. Catharina Netter, et al. Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion. RNA. 2009 Jul;15(7):1305-13. [Content Brief]

[2]. Heike Benecke, et al. The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. EMBO J. 2005 Sep 7;24(17):3057-69. [Content Brief]

[3]. Jesús Argente, et al. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. EMBO Mol Med. 2014 Mar;6(3):299-306. [Content Brief]

[4]. Antto J Norppa, et al. Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA. 2018 Mar;24(3):396-409. [Content Brief]

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