Sarcolipin
Definition:
Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).
References:
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[1]. Alessandro Mascioni, et al. Structure and orientation of sarcolipin in lipid environments. Biochemistry. 2002 Jan 15;41(2):475-82. [Content Brief]
[2]. A Odermatt, et al. Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem. 1998 May 15;273(20):12360-9. [Content Brief]
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