Septin-8

Definition:

Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).; [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.

References:

[1]. Susanne Bläser, et al. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Thromb Haemost. 2004 May;91(5):959-66. [Content Brief]

[2]. Kaisa M A Kurkinen, et al. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016 Jun 1;129(11):2224-38. [Content Brief]

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