Serpin A12

Definition:

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.

References:

[1]. John T Heiker, et al. Vaspin inhibits kallikrein 7 by serpin mechanism. Cell Mol Life Sci. 2013 Jul;70(14):2569-83. [Content Brief]

[2]. Kazuyuki Hida, et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10610-5. [Content Brief]

[3]. Kathrin Oertwig, et al. Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability. Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1188-1194. [Content Brief]

[4]. David Ulbricht, et al. A unique serpin P1' glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin). Biochem J. 2015 Sep 15;470(3):357-67. [Content Brief]

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