Sodium-dependent multivitamin transporter

Definition:

Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate. Required for biotin and pantothenate uptake in the instestine (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier. May also be involved in the sodium-dependent transport of iodide ions.

References:

[1]. Britta Zehnpfennig, et al. Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT). J Biol Chem. 2015 Jun 26;290(26):16372-82. [Content Brief]

[2]. Abhisek Ghosal, et al. Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter. Biochim Biophys Acta. 2012 Jan;1818(1):97-102. [Content Brief]

[3]. Alicia B Byrne, et al. Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6. NPJ Genom Med. 2019 Nov 14;4:28. [Content Brief]

[4]. Veedamali S Subramanian, et al. Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child. Hum Genet. 2017 Feb;136(2):253-261. [Content Brief]

[5]. Krishnaswamy Balamurugan, et al. Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects. Am J Physiol Renal Physiol. 2005 Apr;288(4):F823-31. [Content Brief]

[6]. H Wang, et al. Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. J Biol Chem. 1999 May 21;274(21):14875-83. [Content Brief]

[7]. Fernanda Delmondes de Carvalho, et al. Surprising substrate versatility in SLC5A6: Na+-coupled I- transport by the human Na+/multivitamin transporter (hSMVT). J Biol Chem. 2011 Jan 7;286(1):131-7. [Content Brief]

[8]. Aswani Dutt Vadlapudi, et al. Functional and molecular aspects of biotin uptake via SMVT in human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells. AAPS J. 2012 Dec;14(4):832-42. [Content Brief]

[9]. Yasuo Uchida, et al. Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. J Neurochem. 2015 Jul;134(1):97-112. [Content Brief]

[10]. Abhisek Ghosal, et al. Role of the putative N-glycosylation and PKC-phosphorylation sites of the human sodium-dependent multivitamin transporter (hSMVT) in function and regulation. Biochim Biophys Acta. 2011 Aug;1808(8):2073-80. [Content Brief]

[11]. Ram Lakhan, et al. Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway. Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C376-C384. [Content Brief]

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