Sphingosine 1-phosphate receptor 4
Definition:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
References:
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[1]. J R Van Brocklyn, et al. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. Blood. 2000 Apr 15;95(8):2624-9. [Content Brief]
[2]. Y Yamazaki, et al. Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway. Biochem Biophys Res Commun. 2000 Feb 16;268(2):583-9. [Content Brief]
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