Terminal nucleotidyltransferase 5C

Definition:

Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression. Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

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