Transcription initiation factor TFIID subunit 5

Definition

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8. Involved in contacts between TFIID and TFIIF in the PIC.

References:

[1]. Y Tao, et al. Specific interactions and potential functions of human TAFII100. J Biol Chem. 1997 Mar 7;272(10):6714-21. [Content Brief]

[2]. Xizi Chen, et al. Structural insights into preinitiation complex assembly on core promoters. Science. 2021 Apr 30;372(6541):eaba8490. [Content Brief]

[3]. N Tanese, et al. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13611-6. [Content Brief]

[4]. V Dubrovskaya, et al. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. EMBO J. 1996 Jul 15;15(14):3702-12. [Content Brief]

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