Upstream-binding protein 1

Definition:

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

References:

[1]. H Kato, et al. Repression of HIV-1 transcription by a cellular protein. Science. 1991 Mar 22;251(5000):1476-9. [Content Brief]

[2]. J B Yoon, et al. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. Mol Cell Biol. 1994 Mar;14(3):1776-85. [Content Brief]

[3]. N Huang, et al. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. J Biol Chem. 2000 Jan 28;275(4):2852-8. [Content Brief]

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