Voltage-dependent calcium channel gamma-4 subunit

Definition:

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

References:

[1]. Lin Yang, et al. Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. 2011 Mar;25(3):928-36. [Content Brief]

[2]. Akihiko S Kato, et al. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron. 2010 Dec 22;68(6):1082-96. [Content Brief]

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