BTK-IN-50
BTK-IN-50 is a covalent BTK inhibitor with an IC50 of 6 nM. BTK-IN-50 blocks collagen-induced platelet aggregation by inhibiting the GPVI-mediated BTK-PLCγ2-PKC signaling cascade, and attenuates CRP-XL-induced phosphorylation of BTK, PLCγ2 and PKC substrates in platelets. BTK-IN-50 can be used for research related to thrombosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C25H24ClN5O5
- Masse moléculaire:509.94
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
BTK-IN-50 (19b) acts as a covalent inhibitor of wild-type BTK with an IC50 of 6 nM, and its activity is predominantly dependent on covalent bond formation with BTK's Cys481 residue[1].
BTK-IN-50 (19b) potently inhibits collagen-induced aggregation of human platelets with an IC50 of 16 nM[1].
BTK-IN-50 (19b) (3-30 nM; 15 min preincubation) dose-dependently inhibits the GPVI-mediated BTK-PLCγ2-PKC signaling cascade in washed human platelets at concentrations of 3 nM, 10 nM, and 30 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Masse moléculaire 509.94
-
Formule C25H24ClN5O5
-
SMILES
NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=CN2[C@H]5[C@H](O)[C@H](O)[C@H](CNC(CCl)=O)O5
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-50 Related Classifications
HY-184940 Related Classifications
Powered by Bioz