CHIKV-IN-5
CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV.
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- CAS No.: 2568903-91-1
- Formule: C23H17N5OS2
- Masse moléculaire:443.54
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Activité biologique
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Activité biologique
CHIKV-IN-5 shows good virus titer reduction (VTR = 8.7 log at 10 μM concentration) in normal human dermal fibroblast cells and in vitro mouse microsomal stability (MLMt1/2=74 min)[1].
CHIKV-IN-5 (10 μM, 2 h) blocks CHIKV replication post-entry on NHDF cells[1].
CHIKV-IN-5 (10 μM, pretreats for 1 h) inhibits CHIKV structural protein synthesis but not viral transcription in CHIKV infected NHDF cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CHIKV-IN-5 (0.5-20 mg/kg, i.p., i.v., p.o., s.c.) shows favorable metabolic stability in male C57BL/6 mice [1].
Pharmacokinetic (PK) analysis in mice (CHIKV-IN-5)
| parameters | i.v. | i.p. | p.o. | s.c. |
| t1/2 (h) | 1.78 | 3.52 | 2.38 | 5.70 |
| AUC (h × ng/mL) | 821 | 30648 | 15292 | 1524 |
| Cmax (ng/mL) | - | 2460 | 2100 | 142 |
| %F | - | 91 | 45 | 5 |
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