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Cat. No.: HY-161787

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G9a-IN-2

G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC₅₀ of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD).

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CAS No.: 2648853-26-1
Formule: C₃₀H₄₂N₄O₄
Masse moléculaire:522.68

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

G9a-IN-2 Chemical Structure

CAS No.: 2648853-26-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS No. 2648853-26-1
Masse moléculaire 522.68
Formule C₃₀H₄₂N₄O₄
SMILES

CN(CC1)CCC1OC2=CC=C(NC([C@@H](NC(C3=C(C)C(C(CC(C)(C)C4)=O)=C4N3)=O)CCCC)=O)C=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nishigaya Y, et al., Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorg Med Chem Lett. 2024 Jun 22;110:129856. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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G9a-IN-2

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

G9a-IN-2 Related Classifications

HY-161787 Related Classifications