2648853-26-1
Chemical Structure
G9a-IN-2
- CAS No.: 2648853-26-1
- Formula:C30H42N4O4
- Molecular Weight:522.68
InChIKey: SANTZUMQHHSQMN-QHCPKHFHSA-N
SMILES: CN(CC1)CCC1OC2=CC=C(NC([C@@H](NC(C3=C(C)C(C(CC(C)(C)C4)=O)=C4N3)=O)CCCC)=O)C=C2
Biological Activity: G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC50 of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD)[1].
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G9a-IN-2 | G9a-IN-2 (Compound 7i) is an inhibitor for histone methyltransferases G9a with IC50 of 0.024 μM. G9a-IN-2 reduces H3K9me2 levels and induces the mRNA expression of γ-globin mRNA. G9a-IN-2 shows the potential in ameliorating sickle cell disease (SCD). | |||||||||||||||||||||
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Keywords