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TMEM87A - transmembrane protein 87A Gene

Also Known as ELKIN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25963

About TMEM87A

This gene has 15 transcripts (splice variants), 195 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 20.9), prostate (RPKM 20.6) and 25 other tissues.

Summary

Involved in retrograde transport, endosome to Golgi. Located in Golgi cisterna membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM87A Products (3)

mRNA	Protein	Name
NM_001110503.3	NP_001103973.1	transmembrane protein 87A isoform 2 precursor
NM_001286487.1	NP_001273416.1	transmembrane protein 87A isoform 3
NM_015497.5	NP_056312.2	transmembrane protein 87A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
NOT enables mechanosensitive potassium channel activity	IDA IDA: Inferred from direct assay	36373655	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	32228863	GOA
involved in detection of mechanical stimulus involved in sensory perception of touch	IMP IMP: Inferred from mutant phenotype	38422143	GOA
acts upstream of or within retrograde transport, endosome to Golgi	IGI IGI: Inferred from genetic interaction	26157166	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	32228863	GOA
located in Golgi cisterna membrane	IDA IDA: Inferred from direct assay	26157166	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	32228863	GOA
located in ruffle	IDA IDA: Inferred from direct assay	32228863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM87A Protein Structure

Lung_7-TM_R

0
100
200
300
400
500
555 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 87A

Related Diseases

Diseases	Alias
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Taybi-Linder Syndrome Brachymelic Primordial Dwarfism Cephaloskeletal Dysplasia Low-Birth-Weight Dwarfism With Skeletal Dysplasia Microcephalic Osteodysplastic Primordial Dwarfism Type I Osteodysplastic Primordial Dwarfism Type I Primordial Microcephalic Dwarfism, Crachami Type Osteodysplastic Primordial Dwarfism, Type 1 MOPD1 Mopd I Mopd Osteodysplastic Primordial Dwarfism, Type I Tals Microcephalic Osteodysplastic Primordial Dwarfism Type 1 Mopd 1 Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3 Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii Mopd Types I And Iii Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type Primordial Microcephalic Dwarfism Crachami Type Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Hermansky-Pudlak Syndrome 1	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells HPS1 Delta Storage Pool Disease Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Hermansky-Pudlak Syndrome, Type 1 Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14744	TMEM87A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM87A	VGNC	VGNC:36118
Mus musculus	TMEM87A	MGD	MGI:2441844
Felis catus	TMEM87A	VGNC	VGNC:66367
Macaca mulatta	TMEM87A	VGNC	VGNC:79439
Rattus norvegicus	TMEM87A	RGD	RGD:1309417