GK - glycerol kinase Gene

Also Known as GK1; GKD

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2710

About GK

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,653,423-30,731,462 (from NCBI)

This gene has 12 transcripts (splice variants), 309 orthologues, 6 paralogues and is associated with 4 phenotypes. Broad expression in kidney (RPKM 27.5), small intestine (RPKM 25.1) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GK Products (5)

mRNA	Protein	Name
NM_000167.6	NP_000158.1	glycerol kinase isoform b
NM_001128127.3	NP_001121599.1	glycerol kinase isoform c
NM_001205019.2	NP_001191948.1	glycerol kinase isoform d
NM_001399987.1	NP_001386916.1	glycerol kinase isoform 5
NM_203391.4	NP_976325.1	glycerol kinase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables glycerol kinase activity	IDA IDA: Inferred from direct assay	15845384	GOA
enables glycerol kinase activity	IMP IMP: Inferred from mutant phenotype	8651297	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in glycerol metabolic process	IMP IMP: Inferred from mutant phenotype	8499898	GOA
involved in glycerol-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	15845384	GOA
involved in glycerol-3-phosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	8651297	GOA
involved in triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	8651297	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	15845384	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	15845384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15845384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GK Protein Structure

FGGY_N

FGGY_C

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
glycerol kinase	ATP:glycerol 3-phosphotransferase

GK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	GK	P32189	NR4A1	Homo sapiens	P22736	Pull Down	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

GK Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P83154	Glycerol Kinase Antibody (YA2899)	WB, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glycerol Kinase Deficiency	Hyperglycerolemia GKD Gk Deficiency Gk1 Deficiency Deficiency Of Glycerol Kinase Isolated Glycerol Kinase Deficiency Glycerol Kinase Deficiency, Adult Form Glycerol Kinase Deficiency, Juvenile Form Deficiency, Glycerol Kinase
Adrenal Hypoplasia, Congenital	X-Linked Adrenal Hypoplasia Congenita Congenital Adrenal Hypoplasia AHC Adrenal Hypoplasia, Congenital, With Hypogonadotropic Hypogonadism Adrenal Hypoplasia Congenita X-Linked Ahc Ahch Ahx Ahc With Hhg Cytomegalic Adrenocortical Hypoplasia Ahc With Isolated Gonadotropin Deficiency X-Linked Congenital Adrenal Hypoplasia Congenital Adrenal Hypoplasia, X-Linked Addison Disease, X-Linked Primary Adrenal Hypoplasia Adrenal Hypoplasia Congenital, X-Linked X-Linked Addison Disease X-Linked Adrenal Hypoplasia Congenital Congenital Hypoplasia Of Adrenal Gland Congenital Adrenal Gland Hypoplasia Congenital Small Adrenal Gland Adrenal Hypoplasia Cah - [Congenital Adrenal Hypoplasia]
Ocular Albinism	Albinism, Ocular Oa Xloa Albinism Ocular
Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies	Image Syndrome IMAGE Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies Image Anomaly Image Association Fetal Growth Retardation Pyle Metaphyseal Dysplasia
Muscular Dystrophy, Becker Type	Becker Muscular Dystrophy BMD Benign Pseudohypertrophic Muscular Dystrophy Benign Congenital Myopathy Becker Dystrophinopathy Becker'S Muscular Dystrophy Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Becker Dystrophy, Muscular, Becker Type Dystrophinopathy Becker Dystrophy Becker Type Dystrophy Bmd - [Becker Muscular Dystrophy]
Aland Island Eye Disease	AIED Forsius-Eriksson Type Ocular Albinism Forsius-Eriksson Syndrome Autoimmune Inner Ear Disease Forsius Eriksson Type Ocular Albinism Aland Islands Eye Disease Aaland Island Eye Disease Ocular Albinism, Type Ii
Chromosome Xp21 Deletion Syndrome	Complex Glycerol Kinase Deficiency Xp21 Microdeletion Syndrome Monosomy Xp21 Xp21 Deletion Syndrome Complex Gkd Del Xp21 Contiguous Gene Deletion Syndrome Glycerol Kinase Deficiency - Contiguous Gene Syndrome
Hypoadrenocorticism, Familial	Addison Disease Primary Adrenocortical Insufficiency Addison'S Disease Adrenal Gland Hypofunction Adrenal Hypoplasia Adrenal Aplasia Addison Disease, Chronic Adrenal Insufficiency Primary Hypoadrenalism Hypoadrenocorticism Familial Autoimmune Addison Disease Autoimmune Adrenalitis Classic Addison Disease Primary Addison Disease Addisons Disease Addison Disease, Susceptibility To Autoimmune Primary Adrenal Insufficiency Addison'S Disease Due To Autoimmunity
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Internal Hordeolum
Diabetes Mellitus	Diabetes
Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To	Carbamoyl Phosphate Synthetase I Deficiency Cps I Deficiency Carbamoyl Phosphate Synthetase I Deficiency Disease Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital Hyperammonemia, Type I Carbamoylphosphate Synthetase I Deficiency Carbamoyl Phosphate Synthetase 1 Deficiency CPS1D Carbamoyl Phosphate Synthetase Deficiency Cps 1 Deficiency Carbamyl Phosphate Synthetase Deficiency Hyperammonemia Due To Carbamoyl Phosphate Synthetase 1 Deficiency Carbamyl-Phosphate Synthetase I Deficiency Disease Carbamoyl-Phosphate Synthetase 1 Deficiency Cps1 Deficiency Carbamoyl-Phosphate Synthetase I Deficiency Carbamoyl-Phosphate Synthetase Deficiency Hyperammonemia Due To Carbamoyl Phosphate Synthetase I Deficiency Deficiency, Carbamoylphosphate Synthetase I Carbamylphosphate Synthetase Deficiency
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Deafness, Autosomal Recessive 8	Neurosensory Nonsyndromic Recessive Deafness 8 DFNB8 Dfnb10 Deafness, Autosomal Recessive 10 Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8 Nsrd8 Autosomal Recessive Nonsyndromic Deafness 8 Deafness, Autosomal Recessive 8/10 Autosomal Recessive Deafness 10 Autosomal Recessive Deafness 8 Childhood-Onset Neurosensory Autosomal Recessive Deafness 8 Nrsd8 Deafness, Autosomal Recessive, 8 Childhood-Onset Neurosensory Deafness Autosomal Recessive 8 Deafness Autosomal Recessive 10 Deafness Autosomal Recessive 8/10 Deafness Neurosensory Autosomal Recessive 8 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8 Deafness, Autosomal Recessive, Type 8/10
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-14806B	Teneligliptin hydrobromide hydrate		99.97%	Unkown
HY-14806A	Teneligliptin hydrobromide		99.99%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-109030	Dorzagliatin	Activator	99.89%	Phase 4
HY-144289	BMS-820132	Activator	99.75%	Phase 1

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-12337	GK921	Inhibitor	99.91%	Unkown
HY-134816	D-Glucan		96.0%	Unkown
HY-13802	SC-514	Inhibitor	99.97%	Unkown
HY-153627	GK13S	Inhibitor	99.09%	Unkown
HY-W040127	Peonidin 3-O-glucoside chloride		98.02%	Unkown
HY-13529	Globalagliatin	Activator	99.45%	Unkown
HY-10595	RO-28-1675	Activator	99.89%	Unkown
HY-12411	AMG-3969	Modulator	99.45%	Unkown
HY-122756	N-Palmitoyl-l-leucine	Inhibitor	99.98%	Unkown
HY-147254	Cadisegliatin	Activator	99.80%	Unkown
HY-154914	GK16S		98.0%	Unkown
HY-100221	AM-2394	Activator	99.30%	Unkown
HY-160602	CPL207280	Agonist	98.72%	Unkown
HY-120441	CAY10590		98.0%	Unkown
HY-125986	GK187	Inhibitor	98.0%	Unkown
HY-12614	AMG-1694	Modulator	/	Unkown
HY-144287	Glucokinase activator 3		98.36%	Unkown
HY-153627A	GK13R	Inhibitor	98.93%	Unkown
HY-109030R	Dorzagliatin (Standard)	Activator	98.47%	Unkown
HY-121070	AZD1092	Activator	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-138990	GK563	Inhibitor	/	Unkown
HY-154802	TCO-GK-PEG4-NHS ester		/	Unkown
HY-155328	GK444	Inhibitor	/	Unkown
HY-155329	GK718	Inhibitor	/	Unkown
HY-155448	GK56		/	Unkown
HY-155449	GK60		/	Unkown
HY-155451	GK83		/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-177297	LCZ960	Activator	/	Unkown
HY-D0573	C.I. Solvent red 197		95.54%	Unkown
HY-RS05329	GCK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05330	Gck Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05457	GK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05458	GK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05459	GK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120050	GK470	Inhibitor	/	Unkown
HY-126072	(Rac)-GK563		/	Unkown
HY-136631	PF-04279405	Agonist	/	Unkown
HY-155450	GK81		/	Unkown
HY-158792	GK241		/	Unkown
HY-173103S	FYDPL(Ala-13C3,15N)GK TFA		/	Unkown
HY-179419	Glucokinase activator 10	Activator	/	Unkown
HY-180229	GK730	Inhibitor	/	Unkown
HY-RS17180	Gk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17868	Gk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18388	Galk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23631	Gk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24337	Gk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00411	PSN-GK1	Activator	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990792	Anti-Mouse CD4 Antibody (GK1.5)	Inhibitor	99.16%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GK	MGD	MGI:106594