GK - glycerol kinase Gene

Homo sapiens

Also known as GK1; GKD

Gene ID: 2710 | Gene type: protein coding

About GK

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,653,423-30,731,462 (from NCBI)

This gene has 12 transcripts (splice variants), 309 orthologues, 6 paralogues and is associated with 4 phenotypes. Broad expression in kidney (RPKM 27.5), small intestine (RPKM 25.1) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key Enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GK Products(5)

mRNA	Protein	Name
NM_000167.6	NP_000158.1	glycerol kinase isoform b
NM_001128127.3	NP_001121599.1	glycerol kinase isoform c
NM_001205019.2	NP_001191948.1	glycerol kinase isoform d
NM_001399987.1	NP_001386916.1	glycerol kinase isoform 5
NM_203391.4	NP_976325.1	glycerol kinase isoform a

GK Protein Structure

FGGY_N

FGGY_C

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

glycerol kinase

ATP:glycerol 3-phosphotransferase

Related Diseases

Diseases

Alias

Glycerol Kinase Deficiency

Hyperglycerolemia	GKD
Gk Deficiency	Gk1 Deficiency
Deficiency Of Glycerol Kinase	Isolated Glycerol Kinase Deficiency
Glycerol Kinase Deficiency, Adult Form	Glycerol Kinase Deficiency, Juvenile Form
Deficiency, Glycerol Kinase

Adrenal Hypoplasia, Congenital

X-Linked Adrenal Hypoplasia Congenita	Congenital Adrenal Hypoplasia
AHC	Adrenal Hypoplasia, Congenital, With Hypogonadotropic Hypogonadism
Adrenal Hypoplasia Congenita	X-Linked Ahc
Ahch	Ahx
Ahc With Hhg	Cytomegalic Adrenocortical Hypoplasia
Ahc With Isolated Gonadotropin Deficiency	X-Linked Congenital Adrenal Hypoplasia
Congenital Adrenal Hypoplasia, X-Linked	Addison Disease, X-Linked
Primary Adrenal Hypoplasia	Adrenal Hypoplasia Congenital, X-Linked
X-Linked Addison Disease	X-Linked Adrenal Hypoplasia Congenital
Congenital Hypoplasia Of Adrenal Gland	Congenital Adrenal Gland Hypoplasia
Congenital Small Adrenal Gland	Adrenal Hypoplasia
Cah - [Congenital Adrenal Hypoplasia]

Ocular Albinism

Albinism, Ocular	Oa
Xloa	Albinism Ocular

Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies

Image Syndrome	IMAGE
Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies
Image Anomaly	Image Association
Fetal Growth Retardation	Pyle Metaphyseal Dysplasia

Muscular Dystrophy, Becker Type

Becker Muscular Dystrophy	BMD
Benign Pseudohypertrophic Muscular Dystrophy	Benign Congenital Myopathy
Becker Dystrophinopathy	Becker'S Muscular Dystrophy
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type	Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type
Muscular Dystrophy Becker	Dystrophy, Muscular, Becker Type
Dystrophinopathy	Becker Dystrophy
Becker Type Dystrophy	Bmd - [Becker Muscular Dystrophy]

Aland Island Eye Disease

AIED	Forsius-Eriksson Type Ocular Albinism
Forsius-Eriksson Syndrome	Autoimmune Inner Ear Disease
Forsius Eriksson Type Ocular Albinism	Aland Islands Eye Disease
Aaland Island Eye Disease	Ocular Albinism, Type Ii

Chromosome Xp21 Deletion Syndrome

Complex Glycerol Kinase Deficiency	Xp21 Microdeletion Syndrome
Monosomy Xp21	Xp21 Deletion Syndrome
Complex Gkd	Del
Xp21 Contiguous Gene Deletion Syndrome	Glycerol Kinase Deficiency - Contiguous Gene Syndrome

Hypoadrenocorticism, Familial

Addison Disease	Primary Adrenocortical Insufficiency
Addison'S Disease	Adrenal Gland Hypofunction
Adrenal Hypoplasia	Adrenal Aplasia
Addison Disease, Chronic Adrenal Insufficiency	Primary Hypoadrenalism
Hypoadrenocorticism Familial	Autoimmune Addison Disease
Autoimmune Adrenalitis	Classic Addison Disease
Primary Addison Disease	Addisons Disease
Addison Disease, Susceptibility To	Autoimmune Primary Adrenal Insufficiency
Addison'S Disease Due To Autoimmunity

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Internal Hordeolum

Diabetes Mellitus

Diabetes

Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To

Carbamoyl Phosphate Synthetase I Deficiency	Cps I Deficiency
Carbamoyl Phosphate Synthetase I Deficiency Disease	Carbamoyl-Phosphate Synthase I Deficiency Disease
Congenital Hyperammonemia, Type I	Carbamoylphosphate Synthetase I Deficiency
Carbamoyl Phosphate Synthetase 1 Deficiency	CPS1D
Carbamoyl Phosphate Synthetase Deficiency	Cps 1 Deficiency
Carbamyl Phosphate Synthetase Deficiency	Hyperammonemia Due To Carbamoyl Phosphate Synthetase 1 Deficiency
Carbamyl-Phosphate Synthetase I Deficiency Disease	Carbamoyl-Phosphate Synthetase 1 Deficiency
Cps1 Deficiency	Carbamoyl-Phosphate Synthetase I Deficiency
Carbamoyl-Phosphate Synthetase Deficiency	Hyperammonemia Due To Carbamoyl Phosphate Synthetase I Deficiency
Deficiency, Carbamoylphosphate Synthetase I	Carbamylphosphate Synthetase Deficiency

Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy	DMD
Muscular Dystrophy, Duchenne	Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
Severe Dystrophinopathy, Duchenne Type	Muscular Dystrophy Duchenne
Dystrophy, Muscular, Duchenne Type	Benign Duchenne Muscular Dystrophy
Duchenne Motor Neuron Disease	Duchenne Type Dystrophy
Duchenne-Griesinger Disease

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8	DFNB8
Dfnb10	Deafness, Autosomal Recessive 10
Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8	Nsrd8
Autosomal Recessive Nonsyndromic Deafness 8	Deafness, Autosomal Recessive 8/10
Autosomal Recessive Deafness 10	Autosomal Recessive Deafness 8
Childhood-Onset Neurosensory Autosomal Recessive Deafness 8	Nrsd8
Deafness, Autosomal Recessive, 8	Childhood-Onset Neurosensory Deafness Autosomal Recessive 8
Deafness Autosomal Recessive 10	Deafness Autosomal Recessive 8/10
Deafness Neurosensory Autosomal Recessive 8	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8	Deafness, Autosomal Recessive, Type 8/10

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Myopathy

Muscular Diseases

Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13529	Globalagliatin	Activator	≥98.0%	Phase 2
HY-144289	BMS-820132	Activator	99.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109030	Dorzagliatin	Activator	99.87%	Unkown
HY-12337	GK921	Inhibitor	99.93%	Unkown
HY-13802	SC-514	Inhibitor	99.89%	Unkown
HY-10595	RO-28-1675	Activator	99.95%	Unkown
HY-153627	GK13S	Inhibitor	≥98.0%	Unkown
HY-12411	AMG-3969	Modulator	99.62%	Unkown
HY-120441	CAY10590		≥98.0%	Unkown
HY-100221	AM-2394	Activator	99.48%	Unkown
HY-125986	GK187	Inhibitor	≥98.0%	Unkown
HY-144287	Glucokinase activator 3	Activator	98.36%	Unkown
HY-154914	GK16S		/	Unkown
HY-147254	Cadisegliatin	Activator	99.10%	Unkown
HY-12614	AMG-1694	Modulator	/	Unkown
HY-160602	CPL207280	Agonist	/	Unkown
HY-121070	AZD1092	Activator	/	Unkown
HY-138990	GK563	Inhibitor	/	Unkown
HY-154802	TCO-GK-PEG4-NHS ester		/	Unkown
HY-155328	GK444	Inhibitor	/	Unkown
HY-155329	GK718	Inhibitor	/	Unkown
HY-155448	GK56		/	Unkown
HY-155449	GK60		/	Unkown
HY-155450	GK81		/	Unkown
HY-155451	GK83		/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-RS05457	GK Human Pre-designed siRNA Set A		/	Unkown
HY-RS05458	GK2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS05459	GK5 Human Pre-designed siRNA Set A		/	Unkown
HY-U00411	PSN-GK1	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GK	MGD	MGI:106594
Rattus norvegicus	GK	NCBI

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