Gria4 - glutamate ionotropic receptor AMPA type subunit 4 Gene

Also Known as GluA4; GluR4; GluR-D

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29629

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gria4 Products (3)

mRNA	Protein	Name
NM_001113184.1	NP_001106655.1	glutamate receptor 4 isoform 2 precursor
NM_001113185.1	NP_001106656.1	glutamate receptor 4 isoform 3 precursor
NM_017263.2	NP_058959.2	glutamate receptor 4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables AMPA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	2166337	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	1372042	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	20457909	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11891216	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	2166337	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11036266	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11036266	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19591855	RGD

Cellular Component GO Annotation	Evidence	Références	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12471040	RGD
located in dendrite	IMP IMP: Inferred from mutant phenotype	11036266	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	20032460	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11113346	RGD
part of kainate selective glutamate receptor complex	IDA IDA: Inferred from direct assay	20107073	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11036266	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12603841	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	11036266	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	11113346	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	15610164	RGD
located in synapse	IMP IMP: Inferred from mutant phenotype	11036266	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glutamate receptor 4	AMPA-selective glutamate receptor 4 glutamate receptor, ionotrophic, AMPA 4 glutamate receptor, ionotropic, AMPA 4 glutamate receptor, ionotropic, AMPA4 (alpha 4)

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05794	GRIA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gria4	NCBI	NCBI:2893