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Kainic acid hydrate

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Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures.

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  • Pureté: 99.6%
  • CAS No.: 58002-62-3
  • Formule: C10H17NO5
  • Masse moléculaire:231.25
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Kainic acid hydrate Chemical Structure
    Kainic acid hydrate Chemical Structure
  • Experimental Validation Results for Kainic acid hydrate
  • Experimental Validation Results for Kainic acid hydrate
  • Experimental Validation Results for Kainic acid hydrate
  • Experimental Validation Results for Kainic acid hydrate
  • Experimental Validation Results for Kainic acid hydrate
CAS No.: 58002-62-3
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  • Kainic acid hydrate Chemical Structure
    Kainic acid hydrate Chemical Structure
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    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2025 Jul;28(7):1404-1417. [Abstract]

    Customer Validation
     Kainic Acid (KA, i.p., 24 mg/kg, single dose in mouse model of TLE) administration markedly increased microglial calcium signal in both brain regions.

  • 1/16

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     In the TFP@A-treated group, the number and duration of GS were significantly reduced by the second day of Kainic acid (KA, 0.5 mg/mL, 0.5 µL) treatment, with antiepileptic effects lasting until the third day

  • 1/16

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 29:e08161. [Abstract]

    Customer Validation
     ROCK2 inhibition reversed KA (50 μM)-induced suppression of mitophagy, suggesting mitochondrial normalization.

  • 1/16

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2025 May 17;15(1):172. [Abstract]

    Customer Validation
     KA treatment: Lidocaine (3%) and KA (2 mg/mL) were infused bilaterally into the LC via delivery cannulas connected to the cannula drug delivery system in a 0.2 μL volume per side at a rate of 0.1 μL/10 s 30 min after training. Pharmacological inhibition of the LC reduced conditioned fear memory in mice, whereas activation of the LC reversed the SGB-induced reduction in conditioned fear memory [n = 8, F (3, 28) = 53.26, P < 0.0001; NS + Vehicle vs. NS + Lid, n = 8, P < 0.0001; SGB + Vehicle vs. SGB + KA, n = 8, P < 0.0001].

  • 1/16

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 Apr;26(4):542-554. [Abstract]

    Customer Validation
     At the chronic stage (21 d after i.p., 24 mg/kg KA injection), both PLIN2/BD493 staining and electron microscopy of mouse hippocampus showed accumulation of LDs in neurons and astrocytes but not in microglia or oligodendrocytes.

  • Kainic acid hydrate