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Cat. No.: HY-183720

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M4K2163

M4K2163 is a ALK2 inhibitor that serves as a target protein ligand for the synthesis of PROTACs, such as M4K3250 (HY-183718). M4K2163 induces cytotoxic effects in glioblastoma cells. M4K2163 can be used in the research of diffuse intrinsic pontine glioma and glioblastoma.

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CAS No.: 2600795-21-7
Formule: C₂₄H₂₆FN₃O₂
Masse moléculaire:407.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

M4K2163 Chemical Structure

CAS No.: 2600795-21-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

ALK2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	98 nM Compound: 11b; M4K2163	Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay	[PMID: 32787083]
HEK293	IC₅₀	7475 nM Compound: 11b; M4K2163	Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay	[PMID: 32787083]
HEK293	IC₅₀	2.5 μM Compound: 11b; M4K2163	Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp method Inhibition of human ERG expressed in HEK293 cells after 5 mins by IonWorks barracuda patch clamp method	[PMID: 32787083]

In Vitro

M4K2163 (96 h) reduces viability of U87-MG glioblastoma cells in a dose-dependent manner over 96 h, with cytotoxic activity independent of CRBN recruitment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2600795-21-7
Masse moléculaire 407.48
Formule C₂₄H₂₆FN₃O₂
SMILES

CC1=C(C2=CC=C(N3CCNCC3)C=C2)C=NC=C1C4=CC(OC)=C(F)C(OC)=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Webb DT, et al. Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders. Journal of medicinal chemistry. 2026 May 14;69(9):11524-11546. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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