1045857-53-1
1045857-53-1
Chemical Structure
XM462
- CAS No.: 1045857-53-1
- Formula:C25H51NO3S
- Molecular Weight:445.74
IUPAC Name: N-((2S,3S)-1,3-dihydroxy-4-(tridecylthio)butan-2-yl)octanamide
InChIKey: FOIBJHCOSKEGLA-BJKOFHAPSA-N
SMILES: CCCCCCCC(N[C@@H](CO)[C@H](O)CSCCCCCCCCCCCCC)=O
Biological Activity: XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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XM462 | 99.80% | XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor. | ||||||||||||||||||||
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References
- [1]. Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3(6):946-53. [Content Brief]
- [2]. Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20(10):3173-9. [Content Brief]
Keywords
