104732-22-1
104732-22-1
Chemical Structure
S 8849-1 free base
Synonym(s): Tianeptine metabolite MC5
- CAS No.: 104732-22-1
- Formula:C19H21ClN2O4S
- Molecular Weight:408.90
InChIKey: BYPYVXCZPZLHBO-UHFFFAOYSA-N
SMILES: O=C(CCCCNC1C2=C(N(S(=O)(C3=CC(Cl)=CC=C31)=O)C)C=CC=C2)O
Biological Activity: S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants[1][2].
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S 8849-1 free base | S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants. | |||||||||||||||||||||
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S 8849-1-d4 free base | S 8849-1-d4 (free base) (Tianeptine metabolite MC5-d4) is deuterium labeled S 8849-1 (free base). S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants. | |||||||||||||||||||||
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References
- [1]. Gaulier JM, et al. High-performance liquid chromatographic determination of tianeptine in plasma applied to pharmacokinetic studies. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):407-14. [Content Brief]
- [2]. Szafarz M, et al. Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):185-196. [Content Brief]
