1048-17-5
Chemical Structure
ZIP14-IN-1
Synonym(s): PPTD
- CAS No.: 1048-17-5
- Formula:C21H25N3O
- Molecular Weight:335.44
InChIKey: VBFCKBBGHPJVIS-UHFFFAOYSA-N
SMILES: O=C1NCN(C2=CC=CC=C2)C13CCN(CCC4=CC=CC=C4)CC3
Biological Activity: ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. ZIP 14-IN-1 inhibits ZIP14 while sparing ZIP8 (SLC39A8). ZIP 14-IN-1 efficiently blocks ZIP14-mediated uptake of multiple divalent metals (zinc, iron, manganese and cadmium). ZIP 14-IN-1 binds to a pocket formed at the dimer interface of ZIP14, obstructing the metal transport pathway. ZIP 14-IN-1 effectively reverses the consequent elevation of reactive oxygen species (ROS) and lipid peroxidation, attenuating metal-induced cytotoxicity. ZIP 14-IN-1 can be uses for cancer cachexia research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZIP14-IN-1 | 99.82% | ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. ZIP 14-IN-1 inhibits ZIP14 while sparing ZIP8 (SLC39A8). ZIP 14-IN-1 efficiently blocks ZIP14-mediated uptake of multiple divalent metals (zinc, iron, manganese and cadmium). ZIP 14-IN-1 binds to a pocket formed at the dimer interface of ZIP14, obstructing the metal transport pathway. ZIP 14-IN-1 effectively reverses the consequent elevation of reactive oxygen species (ROS) and lipid peroxidation, attenuating metal-induced cytotoxicity. ZIP 14-IN-1 can be uses for cancer cachexia research. | ||||||||||||||||||||
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- [1]. Hara T, et al. Matsukawa K, Ujihara S, Kawabe T, Taguchi H, Fujishiro H, Jenkitkasemwong S, Nunomura K, Lin B, Fukunaka A, Yoshigai E, Mishima K, Nakagawa S, Knutson MD, Imagawa H, Matsunaga N, Ohdo S, Hamachi I, Sakurai H, Fukada T. Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia. bioRxiv [Preprint]. 2025 Oct 23:2025.10.23.682519. [Content Brief]
Keywords
