111962-89-1
Chemical Structure
RS 49676
- CAS No.: 111962-89-1
- Formula:C25H28ClN3O5
- Molecular Weight:485.96
IUPAC Name: ethyl (4-(((2R,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlorophenethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)carbamate
InChIKey: IYUDMVFWAXEVJA-UKILVPOCSA-N
SMILES: ClC(C=C1)=CC=C1CC[C@@]2(O[C@H](CO2)COC3=CC=C(C=C3)NC(OCC)=O)CN4C=CN=C4
Biological Activity: RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks.
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RS 49676 | RS 49676 is an N-substituted imidazole compound that exhibits strong in vitro activity against endogenous amoebae (ED50 < 0.1 ng/mL), but is ineffective against exogenous amoebae (epimastigotes). In vivo, RS 49676 (100 mg/kg/d, sc, 2 times) can prolong the average survival time of mice infected with Trypanosoma cruzi to more than 11 weeks. | |||||||||||||||||||||
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Keywords
