1146616-18-3
Chemical Structure
VHR-IN-9
- CAS No.: 1146616-18-3
- Formula:C26H26N4O6S4
- Molecular Weight:618.77
InChIKey: CULPOYNTOOOYIX-QJOMJCCJSA-N
SMILES: O=S(C(C=C1)=CC=C1C2=NN(C3=CC=CC=C3)C=C2/C=C4C(N(C(S/4)=S)CCS(=O)(O)=O)=O)(N5CCCCC5)=O
Biological Activity: VHR-IN-9 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 270 nM. VHR-IN-9 shows very weaker inhibitory activity against MKP-1 (IC50 = 2.8 μM), CD45 (IC50 = 1.8 μM), Cdc25A (IC50 = > 10 μM), PTP1B (IC50 = 2.2 μM), and HePTP (IC50 = 2.4 μM). VHR-IN-9 inhibits the proliferation of HeLa cells. VHR-IN-9 can be used for the research of cervical cancer[1].
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VHR-IN-9 | VHR-IN-9 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 270 nM. VHR-IN-9 shows very weaker inhibitory activity against MKP-1 (IC50 = 2.8 μM), CD45 (IC50 = 1.8 μM), Cdc25A (IC50 = > 10 μM), PTP1B (IC50 = 2.2 μM), and HePTP (IC50 = 2.4 μM). VHR-IN-9 inhibits the proliferation of HeLa cells. VHR-IN-9 can be used for the research of cervical cancer. | |||||||||||||||||||||
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Keywords
