1158347-73-9
1158347-73-9
Chemical Structure
BML-280
Synonym(s): VU0285655-1
- CAS No.: 1158347-73-9
- Formula:C25H27N5O2
- Molecular Weight:429.51
IUPAC Name: N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)quinoline-3-carboxamide
InChIKey: WJOCDBUFEUKYNI-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CC=C2N=C1)NCCN(CC3)CCC3(N(C4=CC=CC=C4)CN5)C5=O
Biological Activity: BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BML-280 | 99.64% | BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research. | ||||||||||||||||||||
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References
- [1]. Burkhardt U, et al. Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion. Eur J Pharmacol. 2015 Aug 15;761:398-404. [Content Brief]
- [2]. Tenconi PE, et al. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: New insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019 Jul;184:243-257. [Content Brief]
Keywords
