1189947-02-1
1189947-02-1
Chemical Structure
Promethazine-d6 hydrochloride
Synonym(s): (±)-Promethazine-d6 hydrochloride
- CAS No.: 1189947-02-1
- Formula:C17H15D6ClN2S
- Molecular Weight:326.92
IUPAC Name: N,N-bis(methyl-d3)-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride
InChIKey: XXPDBLUZJRXNNZ-HVTBMTIBSA-N
SMILES: [2H]C([2H])([2H])N(C([2H])([2H])[2H])C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31.Cl
Biological Activity: Promethazine-d6 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is an orally active histamine receptor antagonist[1][2].
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Promethazine-d6 hydrochloride | Promethazine-d6 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is an orally active histamine receptor antagonist. | |||||||||||||||||||||
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Promethazine hydrochloride (Standard) | ≥98% | Promethazine (hydrochloride) (Standard) is the analytical standard of Promethazine (hydrochloride). This product is intended for research and analytical applications. Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors. |
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Promethazine-d3(hydrochloride) | Promethazine-d3 (hydrochloride) is deuterium labeled Promethazine (hydrochloride). Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors. |
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Promethazine-d4 hydrochloride | 95.35% | Promethazine-d4 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors. | ||||||||||||||||||||
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Promethazine hydrochloride | 99.85% | Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors. |
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. [Content Brief]
