1201323-97-8
1201323-97-8
Chemical Structure
MK-3328
- CAS No.: 1201323-97-8
- Formula:C14H9FN4O
- Molecular Weight:268.25
IUPAC Name: 5-fluoro-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)oxazolo[5,4-b]pyridine
InChIKey: WYQHKOHCTMNFAU-UHFFFAOYSA-N
SMILES: CN1C=CC2=CC(C3=NC4=CC=C(F)N=C4O3)=CN=C21
Biological Activity: MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MK-3328 | 99.70% | MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging. | ||||||||||||||||||||
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References
- [1]. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502. [Content Brief]
- [2]. Hostetler ED, et al. [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey. Nucl Med Biol. 2011 Nov;38(8):1193-203. [Content Brief]
Keywords
