120635-25-8
Chemical Structure
Mofegiline hydrochloride
Synonym(s): MDL72974A
- CAS No.: 120635-25-8
- Formula:C11H14ClF2N
- Molecular Weight:233.69
IUPAC Name: (E)-2-(fluoromethylene)-4-(4-fluorophenyl)butan-1-amine hydrochloride
InChIKey: QUCNNQHLIHGBIA-HCUGZAAXSA-N
SMILES: FC1=CC=C(CC/C(CN)=C(F)/[H])C=C1.[H]Cl
Biological Activity: Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Mofegiline hydrochloride | 99.57% | Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. J Neural Transm Park Dis Dement Sect. 1989;1(4):243-54. [Content Brief]
- [2]. Fang J, et al. Effect of L-deprenyl, its structural analogues and some monoamine oxidase inhibitors on dopamine uptake. Neuropharmacology. 1994 Jun;33(6):763-8. [Content Brief]
- [3]. Yu PH, et al. Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species. Biochem Pharmacol. 1992 Jan 22;43(2):307-12. [Content Brief]
Keywords
