1219804-03-1
Chemical Structure
4-Hydroxypropranolol-d7 hydrochloride
Synonym(s): (±)-4-Hydroxy Propranolol-d7 hydrochloride
- CAS No.: 1219804-03-1
- Formula:C16H15D7ClNO3
- Molecular Weight:318.85
IUPAC Name: 4-(2-hydroxy-3-((propan-2-yl-d7)amino)propoxy)naphthalen-1-ol hydrochloride
InChIKey: ROUJENUXWIFONU-BGKGEVRXSA-N
SMILES: OC1=C2C=CC=CC2=C(OCC(O)CNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C=C1.Cl[H]
Biological Activity: 4-Hydroxypropranolol-d7 (hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].
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4-Hydroxypropranolol-d7 hydrochloride | 98.68% | 4-Hydroxypropranolol-d7 (hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties. | ||||||||||||||||||||
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5-Hydroxy propranolol-d5 | 5-Hydroxy Propranolol-d5 is the deuterium labeled 5-Hydroxy Propranolol. | |||||||||||||||||||||
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- [1]. Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43(1):222-35. [Content Brief]
- [2]. Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27(7):857-61. [Content Brief]
- [3]. Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1):85-90.
