1221964-50-6
1221964-50-6
Chemical Structure
PS315
- CAS No.: 1221964-50-6
- Formula:C23H19ClO2
- Molecular Weight:362.85
IUPAC Name: (Z)-3-([1,1'-biphenyl]-4-yl)-5-(4-chlorophenyl)pent-2-enoic acid
InChIKey: KXEKGLNMBLODQT-PGMHBOJBSA-N
SMILES: O=C(O)/C=C(C1=CC=C(C2=CC=CC=C2)C=C1)/CCC3=CC=C(Cl)C=C3
Biological Activity: PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity[1].
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PS315 | PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. | |||||||||||||||||||||
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References
Keywords
