122211-29-4
122211-29-4
Chemical Structure
L 156373
- CAS No.: 122211-29-4
- Formula:C40H54N8O7
- Molecular Weight:758.91
IUPAC Name: 16,24-dibenzyl-13-(sec-butyl)-14-hydroxy-25-methyloctadecahydro-2H,12H-dipyridazino[1,6-a:1',6'-d]pyrrolo[1,2-j][1,4,7,10,13,16]hexaazacyclooctadecine-6,12,15,18,23,26(6aH)-hexaone
InChIKey: IEENMDADGAZPAM-UHFFFAOYSA-N
SMILES: O=C1NC(CC2=CC=CC=C2)C(N(C(C(CC)C)C(N3NCCCC3C(N4NCCCC4C(N(C(CC5=CC=CC=C5)C(N6CCCC16)=O)C)=O)=O)=O)O)=O
Biological Activity: L 156373 is a potent oxytocin receptor antagonist with Ki value of 150 nM[1][2].
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L 156373 | L 156373 is a potent oxytocin receptor antagonist with Ki value of 150 nM. | |||||||||||||||||||||
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References
- [1]. Elbatrawi YM, et al. Total Synthesis of L-156,373 and an oxoPiz Analogue via a Submonomer Approach. Org Lett. 2018 May 4;20(9):2707-2710. [Content Brief]
- [2]. Pettibone DJ, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. [Content Brief]
Keywords
