1346598-22-8
1346598-22-8
Chemical Structure
Belotecan-d7 hydrochloride
- CAS No.: 1346598-22-8
- Formula:C25H21D7ClN3O4
- Molecular Weight:477.00
IUPAC Name: (S)-4-ethyl-4-hydroxy-11-(2-((propan-2-yl-d7)amino)ethyl)-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione hydrochloride
InChIKey: SJKBXKKZBKCHET-RJGVUDMNSA-N
SMILES: O=C1N2C(C3=NC4=CC=CC=C4C(CCNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C3C2)=CC5=C1COC([C@]5(O)CC)=O.Cl
Biological Activity: Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].
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Belotecan-d7 hydrochloride | 99.90% | Belotecan-d7 (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. | ||||||||||||||||||||
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Belotecan hydrochloride | 99.97% | Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142. [Content Brief]
