136765-31-6
136765-31-6
Chemical Structure
Dothiepin-d3
- CAS No.: 136765-31-6
- Formula:C19H18D3NS
- Molecular Weight:298.46
IUPAC Name: (Z)-3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N-methyl-N-(methyl-d3)propan-1-amine
InChIKey: PHTUQLWOUWZIMZ-QRYZPGCSSA-N
SMILES: C(CCN(C([2H])([2H])[2H])C)=C1C=2C(CSC=3C1=CC=CC3)=CC=CC2
Biological Activity: Dothiepin-d3 is the deuterium labeled Dothiepin[1].
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Dothiepin-d3 | Dothiepin-d3 is the deuterium labeled Dothiepin. | |||||||||||||||||||||
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Dothiepin-d6 hydrochloride | Dothiepin-d6 (hydrochloride) is the deuterium labeled Dothiepin hydrochloride. | |||||||||||||||||||||
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Dothiepin | 98.50% | Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis. | ||||||||||||||||||||
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References
