1381761-52-9
Chemical Structure
EPZ-4777
- CAS No.: 1381761-52-9
- Formula:C27H40N8O4
- Molecular Weight:540.66
IUPAC Name: 1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
InChIKey: MTLMDZJUGDUTCP-PTGPVQHPSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C
Biological Activity: EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leukemogenic genes, and selectively kills cells that contain the translocation. EPZ-4777 can be used for cancer research[1].
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EPZ-4777 | EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leukemogenic genes, and selectively kills cells that contain the translocation. EPZ-4777 can be used for cancer research. | |||||||||||||||||||||
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Keywords
