138742-43-5
Chemical Structure
Zankiren
Synonym(s): A-72517
- CAS No.: 138742-43-5
- Formula:C35H55N5O6S2
- Molecular Weight:705.97
IUPAC Name: 2-benzyl-N'-((2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)-3-((4-methylpiperazin-1-yl)sulfonyl)-N'-(3-(thiazol-4-yl)propanoyl)propanehydrazide
InChIKey: YFDSDRDMDDGDFC-HOQQKOLYSA-N
SMILES: CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC([C@H](CC2=CSC=N2)NC([C@@H](CS(=O)(N3CCN(CC3)C)=O)CC4=CC=CC=C4)=O)=O
Biological Activity: Zankiren (A-72517) is an orally active inhibitor for renin. Zankiren exhibits renal vasodilator effect, through reduction of angiotensin II formation without affecting other vasodilator mechanisms[1][2].
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Zankiren | Zankiren (A-72517) is an orally active inhibitor for renin. Zankiren exhibits renal vasodilator effect, through reduction of angiotensin II formation without affecting other vasodilator mechanisms. | |||||||||||||||||||||
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- [1]. Wessale JL, Kleinert HD, Calzadilla SV, Kovar PJ, Rosenberg SH.Effects of renin inhibitor A-72517 on hemodynamics and cardiac function in sodium-depleted dogs.Am J Hypertens. 1993 Jun;6(6 Pt 1):514-21. [Content Brief]
- [2]. Fisher ND, et al., Renal vascular responses to renin inhibition with zankiren in men. Clin Pharmacol Ther. 1995 Mar;57(3):342-8. [Content Brief]
Keywords
