1430067-36-9
Chemical Structure
(-)BI97D6
- CAS No.: 1430067-36-9
- Formula:C36H26O8
- Molecular Weight:586.59
IUPAC Name: 5,5'-dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',4,4'-tetraone
InChIKey: IEJPMWKHSOLTHK-UHFFFAOYSA-N
SMILES: O=C1C2=CC(O)=C(C(CC3=CC=CC=C3)=C2C(C(C)=C1C(C(C4=CC(O)=C(C(CC5=CC=CC=C5)=C46)O)=O)=C(C)C6=O)=O)O
Biological Activity: (-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].
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(-)BI97D6 | (-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells. | |||||||||||||||||||||
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Keywords
