1431329-48-4
Chemical Structure
Hemopressin(human, mouse) TFA
- CAS No.: 1431329-48-4
- Formula:C52H80F3N13O14
- Molecular Weight:1168.27
InChIKey: DNARUOVIRGIROR-KXKZAZQTSA-N
SMILES: O=C(O)[C@H](CC1=CNC=N1)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H]3NCCC3)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Biological Activity: Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models[1][2].
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Hemopressin(human, mouse) TFA | Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models. | |||||||||||||||||||||
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- [1]. Garron T Dodd, et al. The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J Neurosci. 2010 May 26;30(21):7369-76. [Content Brief]
- [2]. Elaine F Toniolo, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. [Content Brief]
Keywords
