143188-53-8
Chemical Structure
Lamivudine triphosphate
Synonym(s): 3TCTP
- CAS No.: 143188-53-8
- Formula:C8H14N3O12P3S
- Molecular Weight:469.20
IUPAC Name: ((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl tetrahydrogen triphosphate
InChIKey: YLEQMGZZMCJKCN-NKWVEPMBSA-N
SMILES: NC(C=CN1[C@@H]2CS[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=O
Biological Activity: Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA[1].
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Lamivudine triphosphate | Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA. | |||||||||||||||||||||
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Keywords
