1454707-25-5
Chemical Structure
MAO-B-IN-44
- CAS No.: 1454707-25-5
- Formula:C34H32N4O8
- Molecular Weight:624.64
InChIKey: HWTMKFXSZDNHBR-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=CC=C(OC)C=C2)CC(C3=CC=C([N+]([O-])=O)C=C3)N(C4=CC=C(OC)C=C4)C1C5=CC=C([N+]([O-])=O)C=C5)OCC
Biological Activity: MAO-B-IN-44 (Compound 4n) is a selective monoamine oxidase B (MAO-B) inhibitor targetin with an IC50 value of 1.01 μM, showing weak inhibition on MAO-A (IC50=14.4 μM). MAO-B-IN-44 reduces degradation of neurotransmitters like dopamine. MAO-B-IN-44 is promising for research of neurodegenerative diseases related to MAO-B abnormalities such as Parkinson’s disease[1].
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MAO-B-IN-44 | MAO-B-IN-44 (Compound 4n) is a selective monoamine oxidase B (MAO-B) inhibitor targetin with an IC50 value of 1.01 μM, showing weak inhibition on MAO-A (IC50=14.4 μM). MAO-B-IN-44 reduces degradation of neurotransmitters like dopamine. MAO-B-IN-44 is promising for research of neurodegenerative diseases related to MAO-B abnormalities such as Parkinson’s disease. | |||||||||||||||||||||
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Keywords
