145904-50-3
Chemical Structure
Petasiphenol
- CAS No.: 145904-50-3
- Formula:C18H16O7
- Molecular Weight:344.32
IUPAC Name: 3-(3,4-dihydroxyphenyl)-2-oxopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate
InChIKey: VMNHBRAHVFOYGK-ZZXKWVIFSA-N
SMILES: O=C(OCC(=O)CC1=CC=C(O)C(O)=C1)C=CC2=CC=C(O)C(O)=C2
Biological Activity: Petasiphenol is a phenolic natural product found in Petasites japonicus, possessing selective inhibitory activity against DNA polymerase λ. Petasiphenol binds to the N-terminal BRCT domain of DNA polymerase λ, with an IC50 of 7.8 μM against DNA polymerase λ. Petasiphenol induces cell growth inhibition, G1 phase cell cycle arrest in human cancer cell lines, and exhibits anti-inflammatory activity against TPA-induced mouse ear inflammation. Petasiphenol can be used for research on cancer and inflammation-related diseases[1][2].
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Petasiphenol | Petasiphenol is a phenolic natural product found in Petasites japonicus, possessing selective inhibitory activity against DNA polymerase λ. Petasiphenol binds to the N-terminal BRCT domain of DNA polymerase λ, with an IC50 of 7.8 μM against DNA polymerase λ. Petasiphenol induces cell growth inhibition, G1 phase cell cycle arrest in human cancer cell lines, and exhibits anti-inflammatory activity against TPA-induced mouse ear inflammation. Petasiphenol can be used for research on cancer and inflammation-related diseases. | |||||||||||||||||||||
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