153660-04-9
Chemical Structure
Rp-8-pCPT-cGMPS
- CAS No.: 153660-04-9
- Formula:C16H15ClN5O6PS2
- Molecular Weight:503.88
IUPAC Name: 2-amino-8-((4-chlorophenyl)thio)-9-((2R,4aR,6R,7R,7aS)-7-hydroxy-2-mercapto-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-6H-purin-6-one
InChIKey: PDTDLUUXNODJIA-UIPAFMNBSA-N
SMILES: O=C(NC(N)=N1)C2=C1N(C(SC3=CC=C(Cl)C=C3)=N2)[C@H]4[C@H](O)[C@H](O[P@@]5(S)=O)[C@@H](CO5)O4
Biological Activity: Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (Ki=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets[1].
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Rp-8-pCPT-cGMPS | Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (Ki=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets. | |||||||||||||||||||||
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Keywords
