1574321-31-5
Chemical Structure
EGFR-IN-139
- CAS No.: 1574321-31-5
- Formula:C27H25ClN2O4
- Molecular Weight:476.95
InChIKey: DAUYQOOHOBMTPB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2OCCOC2=C1)C(O3)=CC4=C3C(C)=NC=C4CN5CC6=C(C=CC=C6)CC5.Cl
Biological Activity: EGFR-IN-139 (compound PD 18) is an epidermal growth factor receptor (EGFR) inhibitor, with IC50s of 12.88 (wild type), 10.84 (L858R/T790M), 42.68 (L858R/T790M/C797S) nM, respectively. EGFR-IN-139 displays strong anticancer activity against A549 and H1975 cancer cell lines, which are highly expressed EGFR. EGFR-IN-139 has a strong selectivity to cancer cells. EGFR-IN-139 can be used for nonsmall cell lung cancer (NSCLC) research[1].
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EGFR-IN-139 | EGFR-IN-139 (compound PD 18) is an epidermal growth factor receptor (EGFR) inhibitor, with IC50s of 12.88 (wild type), 10.84 (L858R/T790M), 42.68 (L858R/T790M/C797S) nM, respectively. EGFR-IN-139 displays strong anticancer activity against A549 and H1975 cancer cell lines, which are highly expressed EGFR. EGFR-IN-139 has a strong selectivity to cancer cells. EGFR-IN-139 can be used for nonsmall cell lung cancer (NSCLC) research. | |||||||||||||||||||||
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Keywords
