159428-42-9
159428-42-9
Chemical Structure
Bis-propargyl-PEG4
- CAS No.: 159428-42-9
- Formula:C14H22O5
- Molecular Weight:270.32
IUPAC Name: 4,7,10,13,16-pentaoxanonadeca-1,18-diyne
InChIKey: FCPHAZIYRMYSTF-UHFFFAOYSA-N
SMILES: C#CCOCCOCCOCCOCCOCC#C
Biological Activity: Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Bis-propargyl-PEG4 | 95.64% | Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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References
- [1]. Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
- [2]. Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.
Keywords
