1619929-59-7
1619929-59-7
Chemical Structure
AKT-IN-25
- CAS No.: 1619929-59-7
- Formula:C14H16N4O
- Molecular Weight:256.30
InChIKey: MKCZINLPKDSDKH-UHFFFAOYSA-N
SMILES: O=C(N1C=C(N=N1)C2=CC=CC=C2)N3CCCCC3
Biological Activity: AKT-IN-25 (Compound 14a) is an inhibitor for Akt, that inhibits the phosphorylation of Akt, and thereby inhibits the PI3K/Akt/mTOR signaling pathway. AKT-IN-25 arrests the cell cycle at G1 phase, inhibits the cell migration of PANC-1, and inhibits the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2 with IC50s of 3.05, 1.32, and 3.85 μM, respectively[1].
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AKT-IN-25 | AKT-IN-25 (Compound 14a) is an inhibitor for Akt, that inhibits the phosphorylation of Akt, and thereby inhibits the PI3K/Akt/mTOR signaling pathway. AKT-IN-25 arrests the cell cycle at G1 phase, inhibits the cell migration of PANC-1, and inhibits the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2 with IC50s of 3.05, 1.32, and 3.85 μM, respectively. | |||||||||||||||||||||
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References
Keywords
