1620017-81-3
1620017-81-3
Chemical Structure
Proxyfan Oxalate
- CAS No.: 1620017-81-3
- Formula:C15H18N2O5
- Molecular Weight:306.31
IUPAC Name: 4-(3-(benzyloxy)propyl)-1H-imidazole oxalate
InChIKey: QVMZCQMJBQSPSW-UHFFFAOYSA-N
SMILES: O=C(O)C(O)=O.C1(CCCOCC2=CC=CC=C2)=CNC=N1
Biological Activity: Proxyfan Oxalate is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan Oxalate is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].
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Proxyfan Oxalate | Proxyfan Oxalate is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan Oxalate is over 1000-fold more potent at H3 receptors than other histamine receptors. | |||||||||||||||||||||
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References
- [1]. X Ligneau, et al. Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50. [Content Brief]
- [2]. R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167(5):1099-110. [Content Brief]
Keywords
