1629166-56-8
Chemical Structure
Antibacterial agent 199
- CAS No.: 1629166-56-8
- Formula:C37H48N6O8
- Molecular Weight:704.81
IUPAC Name: (2E,4E,6E)-N-((S)-1-oxo-3-phenyl-1-(((6S,9S,11aS,17S,20aS)-6,9,10-trimethyl-5,8,11,16,20-pentaoxohexadecahydro-1H,5H,16H-dipyrrolo[2,1-c:2',1'-l][1]oxa[4,7,10,13]tetraazacyclohexadecin-17-yl)amino)propan-2-yl)octa-2,4,6-trienamide
InChIKey: UMDXSUFDIAGURI-YTFXDNJKSA-N
SMILES: O=C(N[C@H](C(N1[C@@H](CCC1)C(N(C)[C@H](C(N[C@@H](C)C(N2[C@H]3CCC2)=O)=O)C)=O)=O)COC3=O)[C@H](CC4=CC=CC=C4)NC(/C=C/C=C/C=C/C)=O
Biological Activity: Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively[1].
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Antibacterial agent 199 | Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively. | |||||||||||||||||||||
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Keywords
