172721-98-1
172721-98-1
Chemical Structure
Lateritin
- CAS No.: 172721-98-1
- Formula:C15H19NO3
- Molecular Weight:261.32
IUPAC Name: (3R,6R)-3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione
InChIKey: YOKBTBNVNCFOBF-CHWSQXEVSA-N
SMILES: O=C(O[C@@H]1C(C)C)[C@@H](CC2=CC=CC=C2)N(C)C1=O
Biological Activity: Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188[1]. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans[2].
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Lateritin | Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188. Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans. | |||||||||||||||||||||
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References
- [1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7. [Content Brief]
- [2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1. [Content Brief]
Keywords
